Article
Evolution and heterogeneity of non-hereditary colorectal cancer revealed by single-cell exome sequencing.
Oncogene - 18 May 2017
Wu H, Zhang X-Y, Hu Z, Hou Q, Zhang H, Li Y, Li S, Yue J, Jiang Z, Weissman S M, Pan X, Ju B-G, Wu S
Abstract excerpt
Recently single-cell whole-exome sequencing (scWES) has deeply expanded and sharpened our knowledge of cancer evolution and subclonality. Herein, with scWES and matched bulk whole-exome sequencing (bulk WES) on two colorectal cancer (CRC) patients with normal or adenomatous polyps, we found that both the adenoma and cancer were of monoclonal origin, and both shared partial mutations in the same signaling...
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