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Article

Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer.

Cancer research - 15 Aug 2025

Xu Xianfeng, Yan Caiwang, Bian Lijun, Li Zhe, Yu Yuhui, Zhu Xia, Gao Yun, Xu Hao, Li Fengyuan, Liu Yao, Sun Ping, Wang Zheng, Fu Yao, Jiang Yue, Dai Juncheng, Ma Hongxia, Hu Zhibin, Shen Hongbing, Li Gang, Wang Cheng, Jin Guangfu

Abstract excerpt

Intestinal metaplasia (IM) represents a precancerous condition associated with an increased risk of gastric cancer. A better understanding of whether and how precancerous lesions progress to gastric cancer is crucial for patient stratification and personalized prevention. In this study, we reconstruct evolutionary trajectories of genomic alterations in 330 multiregion matched samples of IM and tumors from 93...

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Identifiers

PMID: 40378287
DOI: 10.1158/0008-5472.CAN-24-4065

Genes

APC
BMP6
CDH1
CFTR
GKN1
GKN2
MTRR
PIK3CA
TP53

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