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Oncogenic structural aberration landscape in gastric cancer genomes

22 Jun 2023

Abstract excerpt

Structural variants (SVs) are responsible for driver events in gastric cancer (GC); however, their patterns and processes remain poorly understood. Here, we examine 170 GC whole genomes to unravel the oncogenic structural aberration landscape in GC genomes and identify six rearrangement signatures (RSs). Non-random combinations of RSs elucidate distinctive GC subtypes comprising one or a few dominant RS that are...

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PMID: 37349325
DOI: 10.1038/s41467-023-39263-1

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