Article
The somatic mutation landscape of normal gastric epithelium.
Nature - 1 Apr 2025
Coorens Tim H H, Collord Grace, Jung Hyungchul, Wang Yichen, Moore Luiza, Hooks Yvette, Mahbubani Krishnaa, Law Simon Y K, Yan Helen H N, Yuen Siu Tsan, Saeb-Parsy Kourosh, Campbell Peter J, Martincorena Iñigo, Leung Suet Yi, Stratton Michael R
Abstract excerpt
The landscapes of somatic mutation in normal cells inform us about the processes of mutation and selection operative throughout life, providing insight into normal ageing and the earliest stages of cancer development1. Here, by whole-genome sequencing of 238 microdissections2 from 30 individuals, including 18 with gastric cancer, we elucidate the developmental trajectories of normal and malignant gastric...
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