Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.

doi:10.3389/fimmu.2022.922252

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Article

Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C.

Frontiers in immunology - 1 Jan 2022

Vollmers Sarah, Lobermeyer Annabelle, Niehrs Annika, Fittje Pia, Indenbirken Daniela, Nakel Jacqueline, Virdi Sanamjeet, Brias Sebastien, Trenkner Timo, Sauer Gabriel, Peine Sven, Behrens Georg M N, Lehmann Clara, Meurer Anja, Pauli Ramona, Postel Nils, Roider Julia, Scholten Stefan, Spinner Christoph D, Stephan Christoph, Wolf Eva, Wyen Christoph, Richert Laura, Norman Paul J, Sauter Jürgen, Schmidt Alexander H, Hoelzemer Angelique, Altfeld Marcus, Körner Christian

Abstract excerpt

NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating NK cell activity and determining the ability to recognize target cells. Human leukocyte antigen (HLA) class I molecules serve as the primary ligand...

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PMID: 35911762
DOI: 10.3389/fimmu.2022.922252
PMCID: PMC9334850

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