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Article

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.

Journal of acquired immune deficiency syndromes (1999) - 1 May 2016

Galaski Johanna, Ahmad Fareed, Tibroni Nadine, Pujol Francois M, Müller Birthe, Schmidt Reinhold E, Fackler Oliver T

Abstract excerpt

OBJECTIVE: HIV-1 Vpu and Nef proteins downregulate cell surface levels of natural killer (NK) cell ligands but functional consequences of individual downregulation events are unclear. We tested how well-conserved NK cell ligand downregulation is among Vpu and Nef variants isolated from chronic HIV patients. METHODS: Proviral vpu and nef sequences were amplified from 27 chronic HIV patients, subcloned, and tested...

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Share to CD4 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Human Immunodeficiency Virus Proteins

Share to Killer Cells, Natural

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Receptors, Natural Killer Cell

Share to Receptors, Virus

Share to Viral Regulatory and Accessory Proteins

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Identifiers

PMID: 26656785
DOI: 10.1097/QAI.0000000000000917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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