Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.

Cell cycle (Georgetown, Tex.) - 17 Jul 2016

Seo Mihwa, Park Sangsoon, Nam Hong Gil, Lee Seung-Jae V

Abstract excerpt

RNA helicases, which unwind RNAs, are essential for RNA metabolism and homeostasis. However, the roles of RNA helicases in specific physiological processes remain poorly understood. We recently reported that an RNA helicase, HEL-1, promotes long lifespan conferred by reduced insulin/insulin-like growth factor-1 (IGF-1) signaling (IIS) in Caenorhabditis elegans. We also showed that HEL-1 induces the expression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DEAD-box RNA Helicases

Share to Insulin

Share to Longevity

Share to Receptor, IGF Type 1

Share to Reproduction

Share to Stress, Physiological

Source

Open in PubMed Open full text

Identifiers

PMID: 27153157
DOI: 10.1080/15384101.2016.1183845
PMCID: PMC4968901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA helicase SACY-1 is required for longevity caused by various genetic perturbations in Caenorhabditis elegans.PMID 27153157Read ↗

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.Semantic proximity Read ↗

Recent Progress in Regulation of Aging by Insulin/IGF-1 Signaling in Caenorhabditis elegansSemantic proximity Read ↗

Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related diseaseSemantic proximity Read ↗

Combinatorial transcriptomic and genetic dissection of insulin/IGF-1 signaling-regulated longevity in Caenorhabditis elegans.Semantic proximity Read ↗

Regulation of <i>Caenorhabditis elegans</i> lifespan by a proteasomal E3 ligase complexSemantic proximity Read ↗

The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogasterSemantic proximity Read ↗

Two sides of lifespan regulating genes: pro-longevity or anti-longevity?Semantic proximity Read ↗

Role of insulin/insulin-like growth factor 1 signaling pathway in longevitySemantic proximity Read ↗

Lifespan regulation by evolutionarily conserved genes essential for viability.Semantic proximity Read ↗

Transcriptome Analysis of Insulin Signaling-Associated Transcription Factors in C. elegans Reveal Their Genome-Wide Target Genes Specificity and Complexity.Semantic proximity Read ↗

Further Extension of Lifespan by Unc-43/CaMKII and Egl-8/PLCβ Mutations in Germline-Deficient Caenorhabditis elegans.Semantic proximity Read ↗

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.