Two sides of lifespan regulating genes: pro-longevity or anti-longevity?

doi:10.1093/jb/mvr026

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Article

Two sides of lifespan regulating genes: pro-longevity or anti-longevity?

Journal of biochemistry - 1 Apr 2011

Honjoh Sakiko, Nishida Eisuke

Abstract excerpt

Traditionally, ageing has been considered a passive and entropic process, in which damages accumulate on biological macromolecules over time and the accumulated damages lead to a decline in overall physiological functions. However, the discovery of a longevity mutant in the nematode Caenorhabditis elegans has challenged this view. A longevity mutant is a mutant organism, in which a reduction-of-function of a...

Topics

Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Longevity
Mutation

Source

Open in PubMed

Identifiers

PMID: 21372089
DOI: 10.1093/jb/mvr026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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