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Article

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity.

Proceedings of the National Academy of Sciences of the United States of America - 25 May 2010

Henis-Korenblit Sivan, Zhang Peichuan, Hansen Malene, McCormick Mark, Lee Seung-Jae, Cary Michael, Kenyon Cynthia

Abstract excerpt

When unfolded proteins accumulate in the endoplasmic reticulum (ER), the unfolded protein response is activated. This ER stress response restores ER homeostasis by coordinating processes that decrease translation, degrade misfolded proteins, and increase the levels of ER-resident chaperones. Ribonuclease inositol-requiring protein-1 (IRE-1), an endoribonuclease that mediates unconventional splicing, and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20460307
DOI: 10.1073/pnas.1002575107
PMCID: PMC2906894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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