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Regulation of <i>Caenorhabditis elegans</i> lifespan by a proteasomal E3 ligase complex

28 Mar 2007

Abstract excerpt

The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are required for the...

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PMID: 17392428
DOI: 10.1073/pnas.0700638104

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