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Article

Lifespan regulation by evolutionarily conserved genes essential for viability.

PLoS genetics - 6 Apr 2007

Curran Sean P, Ruvkun Gary

Abstract excerpt

Evolutionarily conserved mechanisms that control aging are predicted to have prereproductive functions in order to be subject to natural selection. Genes that are essential for growth and development are highly conserved in evolution, but their role in longevity has not previously been assessed. We screened 2,700 genes essential for Caenorhabditis elegans development and identified 64 genes that extend lifespan...

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Identifiers

PMID: 17411345
DOI: 10.1371/journal.pgen.0030056
PMCID: PMC1847696

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Source receipt: pubmed, retrieved 7 Sept 2026.

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