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Article

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans.

Proceedings of the National Academy of Sciences of the United States of America - 4 Aug 2015

Seo Mihwa, Seo Keunhee, Hwang Wooseon, Koo Hee Jung, Hahm Jeong-Hoon, Yang Jae-Seong, Han Seong Kyu, Hwang Daehee, Kim Sanguk, Jang Sung Key, Lee Yoontae, Nam Hong Gil, Lee Seung-Jae V

Abstract excerpt

The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the...

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Identifiers

PMID: 26195740
DOI: 10.1073/pnas.1505451112
PMCID: PMC4534234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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