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Article

Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.

Structure (London, England : 1993) - 3 May 2016

Zhang Hao, Chang Yu-Chung, Huang Qingqiu, Brennan Mark L, Wu Jinhua

Abstract excerpt

Talin plays an important role in regulating integrin-mediated signaling. Talin function is autoinhibited by intramolecular interactions between the integrin-binding F3 domain and the autoinhibitory domain (R9). We determined the crystal structure of a triple-domain fragment, R7R8R9, which contains R9 and the RIAM (Rap1-interacting adaptor molecule) binding domain (R8). The structure reveals a crystallographic...

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Identifiers

PMID: 27150043
DOI: 10.1016/j.str.2016.02.020
PMCID: PMC4860257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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