Article
Structural basis of kindlin-mediated integrin recognition and activation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 2017
Li Huadong, Deng Yi, Sun Kang, Yang Haibin, Liu Jie, Wang Meiling, Zhang Zhang, Lin Jirong, Wu Chuanyue, Wei Zhiyi, Yu Cong
Abstract excerpt
Kindlins and talins are integrin-binding proteins that are critically involved in integrin activation, an essential process for many fundamental cellular activities including cell-matrix adhesion, migration, and proliferation. As FERM-domain-containing proteins, talins and kindlins, respectively, bind different regions of β-integrin cytoplasmic tails. However, compared with the extensively studied talin, little...
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