Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

doi:10.1016/j.jmb.2008.06.087

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Article

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.

Journal of molecular biology - 26 Sept 2008

Wegener Kate L, Basran Jaswir, Bagshaw Clive R, Campbell Iain D, Roberts Gordon C K, Critchley David R, Barsukov Igor L

Abstract excerpt

Talin is a large cytoskeletal protein that is involved in coupling the integrin family of cell adhesion molecules to the actin cytoskeleton, colocalising with the integrins in focal adhesions (FAs). However, at the leading edge of motile cells, talin colocalises with the hyaluronan receptor layilin in what are thought to be transient adhesions, some of which subsequently mature into more stable FAs. During this...

Topics

Amino Acid Sequence
Animals
Calorimetry
Carrier Proteins
Computer Simulation
Fluorescence
Kinetics
Ligands
Magnetic Resonance Spectroscopy
Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutant Proteins

Mutation

Peptides

Protein Binding

Protein Structure, Secondary

Protein Structure, Tertiary

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Identifiers

PMID: 18638481
DOI: 10.1016/j.jmb.2008.06.087

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