Article
The Structure of the talin head reveals a novel extended conformation of the FERM domain.
Structure (London, England : 1993) - 13 Oct 2010
Elliott Paul R, Goult Benjamin T, Kopp Petra M, Bate Neil, Grossmann J Günter, Roberts Gordon C K, Critchley David R, Barsukov Igor L
Abstract excerpt
FERM domains are found in a diverse superfamily of signaling and adaptor proteins at membrane interfaces. They typically consist of three separately folded domains (F1, F2, F3) in a compact cloverleaf structure. The crystal structure of the N-terminal head of the integrin-associated cytoskeletal protein talin reported here reveals a novel FERM domain with a linear domain arrangement, plus an additional domain F0...
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