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Article

The phosphotyrosine binding-like domain of talin activates integrins.

The Journal of biological chemistry - 14 Jun 2002

Calderwood David A, Yan Boxu, de Pereda Jose M, Alvarez Begoña García, Fujioka Yosuke, Liddington Robert C, Ginsberg Mark H

Abstract excerpt

Cellular regulation of the ligand binding affinity of integrin adhesion receptors (integrin activation) depends on the integrin beta cytoplasmic domains (tails). The head domain of talin binds to several integrin beta tails and activates integrins. This head domain contains a predicted FERM domain composed of three subdomains (F1, F2, and F3). An integrin-activating talin fragment was predicted to contain the F2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11932255
DOI: 10.1074/jbc.M111996200

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The phosphotyrosine binding-like domain of talin activates integrins.PMID 11932255Read ↗

Structural basis of integrin activation by talin.Semantic proximity Read ↗

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Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

Multiple factors contribute to integrin-talin interactions in vivo.Semantic proximity Read ↗

Structural basis for the interaction between the cytoplasmic domain of the hyaluronate receptor layilin and the talin F3 subdomain.Semantic proximity Read ↗

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.Semantic proximity Read ↗

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.Semantic proximity Read ↗

The structure of an interdomain complex that regulates talin activity.Semantic proximity Read ↗

Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.Semantic proximity Read ↗

Structural basis of kindlin-mediated integrin recognition and activation.Semantic proximity Read ↗

Differential Binding of Active and Inactive Integrin to Talin.Semantic proximity Read ↗

The extreme C-terminal region of kindlin-2 is critical to its regulation of integrin activation.Semantic proximity Read ↗

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