Article
Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1.
European journal of cell biology - 1 Sept 2010
Kopp Petra M, Bate Neil, Hansen Tania M, Brindle Nicholas P J, Praekelt Uta, Debrand Emmanuel, Coleman Stacey, Mazzeo Daniela, Goult Benjamin T, Gingras Alexandre R, Pritchard Catrin A, Critchley David R, Monkley Susan J
Abstract excerpt
Talin binds to and activates integrins and is thought to couple them to cytoskeletal actin. However, functional studies on talin have been restricted by the fact that most cells express two talin isoforms. Here we show that human umbilical vein endothelial cells (HUVEC) express only talin1, and that talin1 knockdown inhibited focal adhesion (FA) assembly preventing the cells from maintaining a spread morphology,...
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