Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Binding of Active and Inactive Integrin to Talin.

The protein journal - 1 Jun 2018

Wang Dongchuan, Guo Qiang, Wei Ailin, Li Ang

Abstract excerpt

Bi-directional signaling of integrins plays an important role in platelet and leukocyte function. Talin plays a key role in integrin bi-directional signaling and its binding to integrin is highly regulated. The precise regulation of the recruitment and binding of talin to integrin is still being elucidated. In particular, the recruitment of talin to integrin is controlled by the RAP-1 and RIAM/lamellipodin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Cations, Divalent
Share to Enzyme Activation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Manganese

Share to Oligopeptides

Share to Platelet Glycoprotein GPIIb-IIIa Complex

Share to Protein Conformation

Source

Identifiers

PMID: 29785642
DOI: 10.1007/s10930-018-9776-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Binding of Active and Inactive Integrin to Talin.PMID 29785642Read ↗

Negative regulators of integrin activitySemantic proximity Read ↗

Talin binding to integrin beta tails: a final common step in integrin activation.Semantic proximity Read ↗

Structural basis of integrin activation by talin.Semantic proximity Read ↗

The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation.Semantic proximity Read ↗

Multiple factors contribute to integrin-talin interactions in vivo.Semantic proximity Read ↗

Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.Semantic proximity Read ↗

The phosphotyrosine binding-like domain of talin activates integrins.Semantic proximity Read ↗

Structural basis of kindlin-mediated integrin recognition and activation.Semantic proximity Read ↗

β2 integrin activation and signal transduction in leukocyte recruitmentSemantic proximity Read ↗

A talin mutant that impairs talin-integrin binding in platelets decelerates αIIbβ3 activation without pathological bleeding.Semantic proximity Read ↗

Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling.Semantic proximity Read ↗

Transition from rolling to firm adhesion can be mimicked by extension of integrin alphaLbeta2 in an intermediate affinity state.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.