Article
Rate and molecular spectrum of spontaneous mutations in the bacterium Escherichia coli as determined by whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2012
Lee Heewook, Popodi Ellen, Tang Haixu, Foster Patricia L
Abstract excerpt
Knowledge of the rate and nature of spontaneous mutation is fundamental to understanding evolutionary and molecular processes. In this report, we analyze spontaneous mutations accumulated over thousands of generations by wild-type Escherichia coli and a derivative defective in mismatch repair (MMR), the primary pathway for correcting replication errors. The major conclusions are (i) the mutation rate of a...
Topics
- Adenosine Triphosphatases
- Base Sequence
- Binding Sites
- DNA Methylation
- DNA Mismatch Repair
- DNA Replication
- DNA, Bacterial
- Escherichia coli
- Escherichia coli Proteins
- Genes, Bacterial
- Genome, Bacterial
- INDEL Mutation
- Monte Carlo Method