Article
Determinants of spontaneous mutation in the bacterium Escherichia coli as revealed by whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 3 Nov 2015
Foster Patricia L, Lee Heewook, Popodi Ellen, Townes Jesse P, Tang Haixu
Abstract excerpt
A complete understanding of evolutionary processes requires that factors determining spontaneous mutation rates and spectra be identified and characterized. Using mutation accumulation followed by whole-genome sequencing, we found that the mutation rates of three widely diverged commensal Escherichia coli strains differ only by about 50%, suggesting that a rate of 1-2 × 10(-3) mutations per generation per genome...
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