Article
Temperature responses of mutation rate and mutational spectrum in an Escherichia coli strain and the correlation with metabolic rate.
BMC evolutionary biology - 29 Aug 2018
Chu Xiao-Lin, Zhang Bo-Wen, Zhang Quan-Guo, Zhu Bi-Ru, Lin Kui, Zhang Da-Yong
Abstract excerpt
BACKGROUND: Temperature is a major determinant of spontaneous mutation, but the precise mode, and the underlying mechanisms, of the temperature influences remain less clear. Here we used a mutation accumulation approach combined with whole-genome sequencing to investigate the temperature dependence of spontaneous mutation in an Escherichia coli strain. Experiments were performed under aerobic conditions at 25, 28...
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