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Article

Mutation-based mechanisms of antibiotic resistance.

Microbiology and molecular biology reviews : MMBR - 25 Mar 2026

Misra Rajeev

Abstract excerpt

SUMMARYAntibiotic resistance is a major global health threat, with an estimated 1.14 million deaths in 2021 linked to antibiotic resistance. Mutations naturally arise as bacteria evolve to defend against and survive various environmental challenges, including those exerted by antibiotics. Both overuse and misuse of antibiotics can accelerate selection for resistant bacteria. Misuse can happen when antibiotic...

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PMID: 41631831
DOI: 10.1128/mmbr.00101-25
PMCID: PMC13014776

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