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Article

Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing.

Nature - 30 Jun 2016

Jee Justin, Rasouly Aviram, Shamovsky Ilya, Akivis Yonatan, Steinman Susan R, Mishra Bud, Nudler Evgeny

Abstract excerpt

In 1943, Luria and Delbrück used a phage-resistance assay to establish spontaneous mutation as a driving force of microbial diversity. Mutation rates are still studied using such assays, but these can only be used to examine the small minority of mutations conferring survival in a particular condition. Newer approaches, such as long-term evolution followed by whole-genome sequencing, may be skewed by mutational...

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PMID: 27338792
DOI: 10.1038/nature18313
PMCID: PMC4940094

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