Streptomycin and nalidixic acid elevate the spontaneous genome-wide mutation rate in Escherichia coli.

doi:10.1007/s10709-021-00114-w

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Article

Streptomycin and nalidixic acid elevate the spontaneous genome-wide mutation rate in Escherichia coli.

Genetica - 1 Feb 2021

Ozdemirel Huseyin Ozgur, Ulusal Dilara, Kucukyildirim Celik Sibel

Abstract excerpt

Since antibiotic resistance is a growing public health problem worldwide, it is important to understand how antibiotics and spontaneous mutations cooperate and shape the genome-wide mutation rate and spectrum. Here, we quantitatively evaluate genome-wide mutational profiles of Escherichia coli after long-term subinhibitory exposure to a broad-spectrum (streptomycin) and a narrow-spectrum antibiotic (nalidixic...

Topics

Drug Resistance, Bacterial
Escherichia coli
Genome, Bacterial
Mutagenesis
Mutation
Mutation Rate
Nalidixic Acid
Streptomycin

Source

Open in PubMed

Identifiers

PMID: 33502702
DOI: 10.1007/s10709-021-00114-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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