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Article

A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

Nature communications - 13 Apr 2016

Putnam Christopher D, Srivatsan Anjana, Nene Rahul V, Martinez Sandra L, Clotfelter Sarah P, Bell Sara N, Somach Steven B, de Souza Jorge E S, Fonseca André F, de Souza Sandro J, Kolodner Richard D

Abstract excerpt

Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27071721
DOI: 10.1038/ncomms11256
PMCID: PMC4833866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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