Article
The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.
PLoS genetics - 1 Apr 2011
Stirling Peter C, Bloom Michelle S, Solanki-Patil Tejomayee, Smith Stephanie, Sipahimalani Payal, Li Zhijian, Kofoed Megan, Ben-Aroya Shay, Myung Kyungjae, Hieter Philip
Abstract excerpt
Chromosome instability (CIN) is observed in most solid tumors and is linked to somatic mutations in genome integrity maintenance genes. The spectrum of mutations that cause CIN is only partly known and it is not possible to predict a priori all pathways whose disruption might lead to CIN. To address this issue, we generated a catalogue of CIN genes and pathways by screening ∼ 2,000 reduction-of-function alleles...
Topics
- Alleles
- Chromosomal Instability
- Databases, Genetic
- Genes, Essential
- Genes, Fungal
- Genes, Neoplasm
- Genetic Complementation Test
- Humans
- Mutation
- Neoplasms
- Phenotype
- Saccharomyces cerevisiae
- Telomere