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Article

Leveraging DNA damage response signaling to identify yeast genes controlling genome stability.

G3 (Bethesda, Md.) - 26 Feb 2015

Hendry Jason A, Tan Guihong, Ou Jiongwen, Boone Charles, Brown Grant W

Abstract excerpt

Oncogenesis frequently is accompanied by rampant genome instability, which fuels genetic heterogeneity and resistance to targeted cancer therapy. We have developed an approach that allows precise, quantitative measurement of genome instability in high-throughput format in the Saccharomyces cerevisiae model system. Our approach takes advantage of the strongly DNA damage-inducible gene RNR3, in conjunction with the...

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Identifiers

PMID: 25721128
DOI: 10.1534/g3.115.016576
PMCID: PMC4426383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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