Article
Systematic genome instability screens in yeast and their potential relevance to cancer.
Proceedings of the National Academy of Sciences of the United States of America - 6 Mar 2007
Yuen Karen W Y, Warren Cheryl D, Chen Ou, Kwok Teresa, Hieter Phil, Spencer Forrest A
Abstract excerpt
To systematically identify genes that maintain genome structure, yeast knockout mutants were examined by using three assays that followed marker inheritance in different chromosomal contexts. These screens identified 130 null mutant strains exhibiting chromosome instability (CIN) phenotypes. Differences in both phenotype severity and assay specificity were observed. The results demonstrate the advantages of using...
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