Article
Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae.
Nature - 28 Jun 2001
Myung K, Chen C, Kolodner R D
Abstract excerpt
Gross chromosome rearrangements (GCRs), such as translocations, deletion of a chromosome arm, interstitial deletions and inversions, are often observed in cancer cells. Spontaneous GCRs are rare in Saccharomyces cerevisiae; however, the existence of mutator mutants with increased genome instability suggests that GCRs are actively suppressed. Here we show by genetic analysis that these genome rearrangements...
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