Article

Thermally activated irreversible homogenization of G-quadruplexes in an ALS/FTD-associated gene

2025-06-03

Abstract excerpt

<h4>ABSTRACT</h4> A significant proportion of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) cases exhibit a substantial copy number expansion of the hexanucleotide GGGGCC/GGCCCC sequence in the C9ORF72 gene. The GGGGCC sequence forms a non-canonical DNA structure called a G-quadruplex (G4) which has been associated with the disease states and with nucleic acid condensate formatio...

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Literature Corpus work: 53065dfe-f27a-53b5-9771-c92ebc55bf97
DOI: 10.1101/2025.06.02.657482

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