Article

Monitoring G-quadruplex formation with DNA carriers and solid-state nanopores

2019-10-01

Abstract excerpt

<h4>ABSTRACT</h4> G-quadruplexes (Gq) are guanine-rich DNA structures formed by single-stranded DNA. They are of paramount significance to gene expression regulation, but also drug targets for cancer and human viruses. Current ensemble and single-molecule methods require fluorescent labels, which can affect Gq folding kinetics. Here we introduce, a single-molecule Gq nanopore assay (smGNA) to detect Gqs and kinet...

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Literature Corpus work: 36e4a340-efe1-5567-92f5-612a3324ffcf
DOI: 10.1101/788513

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