Article

Large-scale conformational analysis explains G-quadruplex topological landscape

2025-04-08

Abstract excerpt

G-quadruplexes (G4) are four-stranded nucleic acid structures formed within sequences containing repeated guanine tracts separated by loop regions. Abundant in the human genome, they play crucial roles in transcription regulation and genome maintenance. Although theoretically capable to adopt 26 different folding topologies—primarily differing in loop arrangements—only 14 of these have been observed experimentally...

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Literature Corpus work: 7fab9d06-4e80-5a27-a4ac-cc3cc21c0caf
DOI: 10.1101/2025.04.03.646972

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