Article

Visualizing the impact of disease-associated mutations on G protein–nucleotide interactions

2024-02-01

Abstract excerpt

Activation of G proteins stimulates ubiquitous intracellular signaling cascades essential for life processes. Under normal physiological conditions, nucleotide exchange is initiated upon the formation of complexes between a G protein and G protein-coupled receptor (GPCR), which facilitates exchange of bound GDP for GTP, subsequently dissociating the trimeric G protein into its Gα and Gβγ subunits. However, single...

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Literature Corpus work: 5d21caf0-9fa1-50e9-bd9c-29b0e321db7f
DOI: 10.1101/2024.01.30.578006

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