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Article

Parallel reaction pathways accelerate folding of a guanine quadruplex.

Nucleic acids research - 22 Feb 2021

Harkness Robert W, Hennecker Christopher, Grün J Tassilo, Blümler Anja, Heckel Alexander, Schwalbe Harald, Mittermaier Anthony K

Abstract excerpt

G-quadruplexes (G4s) are four-stranded, guanine-rich nucleic acid structures that can influence a variety of biological processes such as the transcription and translation of genes and DNA replication. In many cases, a single G4-forming nucleic acid sequence can adopt multiple different folded conformations that interconvert on biologically relevant timescales, entropically stabilizing the folded state. The...

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PMID: 33469659
DOI: 10.1093/nar/gkaa1286
PMCID: PMC7897495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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