Article
DNA metastability and biological regulation: conformational dynamics of metastable omega-DNA bulge loops.
Journal of the American Chemical Society - 25 Apr 2007
Völker Jens, Klump Horst H, Breslauer Kenneth J
Abstract excerpt
Dynamic interchange between DNA conformations, including metastable states, can be of importance to biological function. In this study, we use a combination of spectroscopic and calorimetric techniques to detect and characterize kinetically trapped, metastable states in strand exchange and strand displacement reactions for bulge loop DNA conformations, here referred to as Omega-DNAs. We show that such metastable,...
Topics
- Base Sequence
- DNA
- Gene Expression Regulation
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Oligodeoxyribonucleotides
- Spectrum Analysis
- Temperature
- Thermodynamics
- Ultraviolet Rays