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Article

Improving the catalytic activity of isopentenyl phosphate kinase through protein coevolution analysis.

Scientific reports - 7 Apr 2016

Liu Ying, Yan Zhihui, Lu Xiaoyun, Xiao Dongguang, Jiang Huifeng

Abstract excerpt

Protein rational design has become more and more popular for protein engineering with the advantage of biological big-data. In this study, we described a method of rational design that is able to identify desired mutants by analyzing the coevolution of protein sequence. We employed this approach to evolve an archaeal isopentenyl phosphate kinase that can convert dimethylallyl alcohol (DMA) into precursor of...

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Identifiers

PMID: 27052337
DOI: 10.1038/srep24117
PMCID: PMC4823809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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