Article
Rational Enzyme Evolution by Facilitating Correlated Motion along the Reaction.
The journal of physical chemistry. B - 5 Jun 2025
Wang Lianxin, Xue Yuanfei, Wang Jia-Ning, Mo Yan, Mei Ye
Abstract excerpt
Enzymes are highly efficient and specific protein catalysts that play an essential role in regulating metabolic processes in living organisms. By modulating the rates of chemical reactions, enzymes tune fundamental crucial biological functions. Directed evolution is a widely used strategy to enhance protein functionality by selecting variants with desirable traits through random mutation and recombination....
Topics
- Directed Molecular Evolution
- Mutation
- Biocatalysis
- Enzymes