Coevolution-based prediction of protein-protein interactions in polyketide biosynthetic assembly lines

Abstract excerpt

Polyketide synthases are multimodular enzymes that generate diverse molecules of great pharmaceutical importance, including a range of clinically used antimicrobials and antitumor agents. Many polyketides are synthesized by type I polyketide synthases (PKSs), which are organized in assembly lines, in which multiple enzymes line up in a specific order. This order is defined by specific protein-protein interactions....

Topics

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• Acyl Carrier Protein
• Algorithms
• Binding Sites
• Catalytic Domain
• Models, Molecular
• Polyketide Synthases
• Protein Conformation
• Protein Interaction Domains and Motifs

Identifiers and source

Literature Corpus work

d1b5f3c0-5b51-5c4b-ba9d-0fe13e912ec3

DOI

10.1101/669291