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Article

Rational engineering of enzyme allosteric regulation through sequence evolution analysis.

PLoS computational biology - 1 Jan 2012

Yang Jae-Seong, Seo Sang Woo, Jang Sungho, Jung Gyoo Yeol, Kim Sanguk

Abstract excerpt

Control of enzyme allosteric regulation is required to drive metabolic flux toward desired levels. Although the three-dimensional (3D) structures of many enzyme-ligand complexes are available, it is still difficult to rationally engineer an allosterically regulatable enzyme without decreasing its catalytic activity. Here, we describe an effective strategy to deregulate the allosteric inhibition of enzymes based...

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Identifiers

PMID: 22807670
DOI: 10.1371/journal.pcbi.1002612
PMCID: PMC3395594

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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