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Computational and deep-learning-guided design of raspberry ketone synthase towards concurrent gains in activity and thermostability.

Bioresource technology - 1 Oct 2026

Yang Yang, Shang Kangkang, Shan Ruoyun, Zheng Pu, Wu Dan, Chen Pengcheng, Yuan Jifeng

Abstract excerpt

Raspberry ketone synthase is the key enzyme for raspberry ketone biosynthesis, yet its activity and thermostability remain suboptimal for industrial use. By combining computational and deep-learning-guided design, we obtained a Rubus idaeus raspberry ketone synthase (RiRZS1) mutant M3 with 12.06-fold higher relative activity and 38.71-fold improved thermostability compared with the wild type. Kinetic analysis...

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PMID: 42173379
DOI: 10.1016/j.biortech.2026.134952

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