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G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells

24 Mar 2016

Abstract excerpt

DNA methylation at imprinting control regions (ICRs) is established in gametes in a sex-specific manner and has to be stably maintained during development and in somatic cells to ensure the correct monoallelic expression of imprinted genes. In addition to DNA methylation, the ICRs are marked by allele-specific histone modifications. Whether these marks are essential for maintenance of genomic imprinting is...

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PMID: 27052169
DOI: 10.1016/j.celrep.2016.03.007

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