Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.

Developmental cell - 22 Nov 2021

Aronson Boaz E, Scourzic Laurianne, Shah Veevek, Swanzey Emily, Kloetgen Andreas, Polyzos Alexander, Sinha Abhishek, Azziz Annabel, Caspi Inbal, Li Jiexi, Pelham-Webb Bobbie, Glenn Rachel A, Vierbuchen Thomas, Wichterle Hynek, Tsirigos Aristotelis, Dawlaty Meelad M, Stadtfeld Matthias, Apostolou Effie

Abstract excerpt

Loss of imprinting (LOI) results in severe developmental defects, but the mechanisms preventing LOI remain incompletely understood. Here, we dissect the functional components of the imprinting control region of the essential Dlk1-Dio3 locus (called IG-DMR) in pluripotent stem cells. We demonstrate that the IG-DMR consists of two antagonistic elements: a paternally methylated CpG island that prevents recruitment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Binding Proteins
Share to Chromosomes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Genomic Imprinting

Share to Intercellular Signaling Peptides and Proteins

Share to Iodide Peroxidase

Share to Promoter Regions, Genetic

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 34710357
DOI: 10.1016/j.devcel.2021.10.004
PMCID: PMC8628258

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus.PMID 34710357Read ↗

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locusSemantic proximity Read ↗

TET3 protects the Dlk1-Dio3 Imprinted Locus from DNA hypomethylation during adult NSC ReprogrammingSemantic proximity Read ↗

Epigenome editing reveals core DNA methylation for imprinting control in the Dlk1-Dio3 imprinted domain.Semantic proximity Read ↗

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domainSemantic proximity Read ↗

A tandem repeat array in IG-DMR is essential for imprinting of paternal allele at the Dlk1-Dio3 domain during embryonic development.Semantic proximity Read ↗

Deletion of conserved sequences in IG-DMR at Dlk1-Gtl2 locus suggests their involvement in expression of paternally expressed genes in mice.Semantic proximity Read ↗

Protocol for DNA Methylation Editing of Imprinted Loci and Assessment of the Effects.Semantic proximity Read ↗

Genomic imprinting at the mammalian Dlk1-Dio3 domainSemantic proximity Read ↗

Methylation dynamics of IG-DMR and Gtl2-DMR during murine embryonic and placental development.Semantic proximity Read ↗

ICR Noncoding RNA Expression Controls Imprinting and DNA Replication at the Dlk1-Dio3 DomainSemantic proximity Read ↗

Regulation of the imprinted Dlk1-Dio3 locus by allele-specific enhancer activity.Semantic proximity Read ↗

At Least Ten Genes Define the Imprinted Dlk1-Dio3 Cluster on Mouse Chromosome 12qF1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.