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Article

Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2002

Onyango Patrick, Jiang Shan, Uejima Hiroshi, Shamblott Michael J, Gearhart John D, Cui Hengmi, Feinberg Andrew P

Abstract excerpt

Imprinting is an epigenetic modification leading to monoallelic expression of some genes, and disrupted imprinting is believed to be a barrier to human stem cell transplantation, based on studies that suggest that epigenetic marks are unstable in mouse embryonic germ (EG) and embryonic stem (ES) cells. However, stem cell imprinting has not previously been examined directly in humans. We found that three imprinted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12114541
DOI: 10.1073/pnas.152327599
PMCID: PMC124986

Genes

IGF2
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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