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Article

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.

The EMBO journal - 22 Oct 2008

Tachibana Makoto, Matsumura Yasuko, Fukuda Mikiko, Kimura Hiroshi, Shinkai Yoichi

Abstract excerpt

Methylation of DNA and lysine 9 of histone H3 (H3K9) are well-conserved epigenetic marks for transcriptional silencing. Although H3K9 methylation directs DNA methylation in filamentous fungi and plants, this pathway has not been corroborated in mammals. G9a and GLP/Eu-HMTase1 are two-related mammalian lysine methyltransferases and a G9a/GLP heteromeric complex regulates H3K9 methylation of euchromatin. To...

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Identifiers

PMID: 18818694
DOI: 10.1038/emboj.2008.192
PMCID: PMC2572175

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G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.PMID 18818694Read ↗

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