Article
G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription.
The EMBO journal - 22 Oct 2008
Tachibana Makoto, Matsumura Yasuko, Fukuda Mikiko, Kimura Hiroshi, Shinkai Yoichi
Abstract excerpt
Methylation of DNA and lysine 9 of histone H3 (H3K9) are well-conserved epigenetic marks for transcriptional silencing. Although H3K9 methylation directs DNA methylation in filamentous fungi and plants, this pathway has not been corroborated in mammals. G9a and GLP/Eu-HMTase1 are two-related mamm...
Topics
- Animals
- Catalysis
- CpG Islands
- DNA Methylation
- Embryonic Stem Cells
- Gene Expression Regulation
- Gene Silencing
- Histone-Lysine N-Methyltransferase
- Histones
- Mice
- Mice, Knockout
- Models, Biological
- Mutation
- Transcription, Genetic