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Article

Effects of Dppa3 on DNA Methylation Dynamics During Primordial Germ Cell Development in Mice1

18 Apr 2013

Abstract excerpt

DNA methylation is a central epigenetic event that regulates cellular differentiation, reprogramming, and pathogenesis. Genomewide DNA demethylation occurs in preimplantation embryos and in embryonic germ cell precursors called primordial germ cells (PGCs). We previously showed that Dppa3, also known as Stella and PGC7, protects the maternal genome from tet methylcytosine dioxygenase 3 (Tet3)-mediated conversion...

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PMID: 23595900
DOI: 10.1095/biolreprod.112.105932

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