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Article

Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.

Genes & development - 15 Feb 2015

Liu Nan, Zhang Zhuqiang, Wu Hui, Jiang Yonghua, Meng Lingjun, Xiong Jun, Zhao Zuodong, Zhou Xiaohua, Li Jia, Li Hong, Zheng Yong, Chen She, Cai Tao, Gao Shaorong, Zhu Bing

Abstract excerpt

GLP and G9a are major H3K9 dimethylases and are essential for mouse early embryonic development. GLP and G9a both harbor ankyrin repeat domains that are capable of binding H3K9 methylation. However, the functional significance of their recognition of H3K9 methylation is unknown. Here, we report that the histone methyltransferase activities of GLP and G9a are stimulated by neighboring nucleosomes that are...

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Identifiers

PMID: 25637356
DOI: 10.1101/gad.254425.114
PMCID: PMC4335294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability.PMID 25637356Read ↗

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