Article

A bipartite element with allele-specific functions safeguards DNA methylation imprints at the <i>Dlk1-Dio3</i> locus

2020-05-24

Abstract excerpt

<h4>SUMMARY</h4> Dysregulation of imprinted gene loci also referred to as loss of imprinting (LOI) can result in severe developmental defects and other diseases, but the molecular mechanisms that ensure imprint stability remain incompletely understood. Here, we dissect the functional components of the imprinting control region of the essential Dlk1-Dio3 locus (called IG-DMR) and the mechanism by which they ensur...

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Literature Corpus work: 1c4bbe42-f1d1-5379-bd77-990d010a27d2
DOI: 10.1101/2020.05.22.103796

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