Article
Inflammatory Th1 and Th17 in the Intestine Are Each Driven by Functionally Specialized Dendritic Cells with Distinct Requirements for MyD88.
Cell reports - 25 Oct 2016
Liang Jie, Huang Hsin-I, Benzatti Fernanda P, Karlsson Amelia B, Zhang Junyi J, Youssef Nourhan, Ma Averil, Hale Laura P, Hammer Gianna E
Abstract excerpt
Normal dynamics between microbiota and dendritic cells (DCs) support modest numbers of T cells, yet these do not cause inflammation. The DCs that induce inflammatory T cells and the signals that drive this process remain unclear. Here, we demonstrate that small intestine DCs lacking the signaling attenuator A20 induce inflammatory T cells and that the signals perceived and antigen-presenting cell (APC) functions...
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