Article
Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis.
American journal of physiology. Gastrointestinal and liver physiology - 1 Jun 2011
Fujiwara Daisuke, Chen Ling, Wei Bo, Braun Jonathan
Abstract excerpt
The large (LI) and small intestine (SI) differ in patterns of susceptibility to chronic mucosal inflammation. In this study, we evaluated whether this might, in part, reflect differences in resident mucosal CD11c(+) T cells. These cells comprised 39-48% (SI) and 12-17% (LI) of the intraepithelial compartment, most of which were T-cell receptor-αβ(+). In the SI, the majority of these cells were CD103(+) CD8(+)...
Topics
- Analysis of Variance
- Animals
- CD11c Antigen
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Colitis
- Colon
- Cytokines
- DNA-Binding Proteins
- Disease Models, Animal
- GTP-Binding Protein alpha Subunit, Gi2